Thomas Jefferson University-Hou Laboratory in Philadelphia, PA is a renowned research facility led by Professor Ya-Ming Hou, PhD. Their research focuses on the essential role of tRNA molecules in cell growth and the origins of the genetic code. Through biochemical, structural, and bioinformatic approaches, they aim to gain insights into tRNA functions and develop strategies for drug targeting against diseases related to tRNA errors.
Their research projects include investigating how tRNA methylation regulates gene expression, understanding the specific methylation and charging of tRNA molecules, and exploring the molecular basis of human diseases caused by impaired tRNA charging. With a broad network of collaborators and a database of related enzymes, Thomas Jefferson University-Hou Laboratory is at the forefront of tRNA research and its implications for various fields of study.
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