Dr. Lee Lab

The Adrian Lee Lab in Pittsburgh, PA is dedicated to translational breast cancer research, with a focus on targeting the insulin-like growth factor pathway and studying the role of massively parallel sequencing in precision cancer genomic medicine.

The lab conducts comprehensive studies on the downstream signaling intermediates of the insulin receptor substrates, analyzes interactions with steroid hormone receptors, and investigates the mechanisms of transformation of mammary epithelial cells. Additionally, they explore the role of genomic alterations and molecular changes during progression, with a particular emphasis on DNA and RNA structural rearrangements in metastasis.

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