St. Isaac Jogues is one of three large Catholic churches in Niles, and it serves the northern part of town. It offers a religious education program for the children of the parish, though it does not have a school.
The parish offers a full range of activities throughout the year, from an Our Lady of Knock Mass to honor Our Lady's appearance in Knock, Ireland in 1879, to an Italian St. Joseph Table in March, the Polish Feast of Our Lady of Czestochowa in August and the Filipino celebration of Simbang Gabi in December.