Lisle Senior High School educates more than 500 students each year, with an average class size of 18. In addition to core classes, students may also enroll in driver's education, foreign languages, fine arts and career and technical education classes.
Lisle High School provides both a special education program and health services to its students.
The HS Home and School Organization provides informational sessions for parents on topics such as financial aid and services to the school that include new benches, special lunches and water bottles for events. It sponsors 50/50 raffles at home football games, along with a holiday craft fair. The high school also encourages its students to participate in both school and community service, and recently initiated the policy of making note of any such activities on students' transcripts.