The Staley Lab at the University of Chicago is a leading research facility dedicated to unraveling the intricacies of pre-mRNA splicing. Through a combination of genetic, biochemical, and genome-wide techniques, the lab investigates the mechanisms and effects of changes in splicing, shedding light on the regulation of cellular function and development. With a focus on splicing catalysis, DEAH-box helicase translocation, alternative splice site selection, fidelity of splicing, and spliceosome dynamics, the Staley Lab has made significant contributions to the field. Their groundbreaking work has not only deepened our understanding of the spliceosome's inner workings but also revealed the potential implications of misregulation in diseases such as retinitis pigmentosa. Led by Principal Investigator Jon Staley, the lab boasts a team of dedicated researchers and alumni who continue to push the boundaries of splicing research.Generated from the website