OLDEST EATING HOUSE IN THE KEYS Pepe's Cafe is the oldest eatery in the Florida Keys, and 2nd Oldest in the State of Florida. Harry Truman was a regular, along with many others whose photos are hanging on our walls. Our juices are fresh-squeezed and our oysters are shucked to order. Breads are fresh-made daily, and the only freezer in the House is for the ice cream. We make our own salad dressings as well as our Proprietary Hot Sauces. Happy Hour 4-6pm
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