The HNRC (HIV Neurobehavioral Research Center) in San Diego, CA is a renowned institution dedicated to advancing neuroAIDS research. With a focus on understanding the impact of HIV infection on mental health and cognitive function, the center's scientific cores and developmental core work together to provide the necessary techniques and resources for cutting-edge research in neurobehavioral and psychiatric aspects of HIV. Through comprehensive assessments, biomarker assays, and advanced imaging techniques, the center aims to uncover the underlying neural mechanisms of mental health disorders in the context of HIV, while also investigating the role of viral epigenetics, co-infections, and mitochondrial biogenesis in neurocognitive outcomes.
At the HNRC, the NeuroMedical Core evaluates the impact of HIV infection and comorbid conditions on mental health outcomes, while the NeuroBehavioral and Psychiatry Core focuses on identifying changes in cognition and daily functioning among individuals with HIV. The NeuroVirology and Biology Core investigates viral persistence in the central nervous system, co-infections, and the response of brain cells to inflammation and antiretroviral therapy. With a commitment to international harmonization of assessments and the development of new methods, the HNRC is at the forefront of neuroHIV research, contributing to advancements in understanding and treating the complex relationships between neurocognition, mental health, and HIV disease.
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